Crosstalk between mitochondrial metabolism and oxidoreductive homeostasis: a new perspective for understanding the effects of bioactive dietary compounds.
Identifieur interne : 000045 ( Main/Exploration ); précédent : 000044; suivant : 000046Crosstalk between mitochondrial metabolism and oxidoreductive homeostasis: a new perspective for understanding the effects of bioactive dietary compounds.
Auteurs : Mariangela Di Giacomo [Italie] ; Vincenzo Zara [Italie] ; Paolo Bergamo [Italie] ; Alessandra Ferramosca [Italie]Source :
- Nutrition research reviews [ 1475-2700 ] ; 2020.
Abstract
Mitochondria play an important role in a number of fundamental cellular processes, including energy production, biosynthetic pathways and cellular oxidoreductive homeostasis (redox status), and their dysfunction can lead to numerous pathophysiological consequences. As the biochemical mechanisms orchestrating mitochondrial metabolism and redox homeostasis are functionally linked, mitochondria have been identified as a potential therapeutic target. Consequently, considerable effort has been made to evaluate the efficacy of natural compounds that modulate mitochondrial function. Molecules produced by plants (for example, polyphenols and isothiocyanates) have been shown to modulate mitochondrial metabolism/biogenesis and redox status; however, despite the existence of a functional link, few studies have considered the combined efficacy of these mitochondrial functions. The present review provides a complete overview of the molecular pathways involved in modulating mitochondrial metabolism/biogenesis and redox status. Crosstalk between these critical mechanisms is also discussed, whilst major data from the literature regarding their antioxidant abilities are described and critically analysed. We also provide a summary of recent evidence regarding the ability of several plant-derived compounds to target these mitochondrial functions. An in-depth understanding of the functional link between mitochondrial metabolism/biogenesis and redox status could facilitate the analysis of the biological effects of natural compounds as well as the development of new therapeutic approaches.
DOI: 10.1017/S0954422419000210
PubMed: 31615587
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Crosstalk between mitochondrial metabolism and oxidoreductive homeostasis: a new perspective for understanding the effects of bioactive dietary compounds.</title><author><name sortKey="Di Giacomo, Mariangela" sort="Di Giacomo, Mariangela" uniqKey="Di Giacomo M" first="Mariangela" last="Di Giacomo">Mariangela Di Giacomo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biological and Environmental Sciences and Technologies, University of Salento, Lecce</wicri:regionArea><wicri:noRegion>Lecce</wicri:noRegion></affiliation></author><author><name sortKey="Zara, Vincenzo" sort="Zara, Vincenzo" uniqKey="Zara V" first="Vincenzo" last="Zara">Vincenzo Zara</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biological and Environmental Sciences and Technologies, University of Salento, Lecce</wicri:regionArea><wicri:noRegion>Lecce</wicri:noRegion></affiliation></author><author><name sortKey="Bergamo, Paolo" sort="Bergamo, Paolo" uniqKey="Bergamo P" first="Paolo" last="Bergamo">Paolo Bergamo</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Food Sciences, National Research Council (CNR-ISA), Avellino, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Food Sciences, National Research Council (CNR-ISA), Avellino</wicri:regionArea><wicri:noRegion>Avellino</wicri:noRegion></affiliation></author><author><name sortKey="Ferramosca, Alessandra" sort="Ferramosca, Alessandra" uniqKey="Ferramosca A" first="Alessandra" last="Ferramosca">Alessandra Ferramosca</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biological and Environmental Sciences and Technologies, University of Salento, Lecce</wicri:regionArea><wicri:noRegion>Lecce</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:31615587</idno><idno type="pmid">31615587</idno><idno type="doi">10.1017/S0954422419000210</idno><idno type="wicri:Area/Main/Corpus">000066</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000066</idno><idno type="wicri:Area/Main/Curation">000066</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000066</idno><idno type="wicri:Area/Main/Exploration">000066</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Crosstalk between mitochondrial metabolism and oxidoreductive homeostasis: a new perspective for understanding the effects of bioactive dietary compounds.</title><author><name sortKey="Di Giacomo, Mariangela" sort="Di Giacomo, Mariangela" uniqKey="Di Giacomo M" first="Mariangela" last="Di Giacomo">Mariangela Di Giacomo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biological and Environmental Sciences and Technologies, University of Salento, Lecce</wicri:regionArea><wicri:noRegion>Lecce</wicri:noRegion></affiliation></author><author><name sortKey="Zara, Vincenzo" sort="Zara, Vincenzo" uniqKey="Zara V" first="Vincenzo" last="Zara">Vincenzo Zara</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biological and Environmental Sciences and Technologies, University of Salento, Lecce</wicri:regionArea><wicri:noRegion>Lecce</wicri:noRegion></affiliation></author><author><name sortKey="Bergamo, Paolo" sort="Bergamo, Paolo" uniqKey="Bergamo P" first="Paolo" last="Bergamo">Paolo Bergamo</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Food Sciences, National Research Council (CNR-ISA), Avellino, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Food Sciences, National Research Council (CNR-ISA), Avellino</wicri:regionArea><wicri:noRegion>Avellino</wicri:noRegion></affiliation></author><author><name sortKey="Ferramosca, Alessandra" sort="Ferramosca, Alessandra" uniqKey="Ferramosca A" first="Alessandra" last="Ferramosca">Alessandra Ferramosca</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biological and Environmental Sciences and Technologies, University of Salento, Lecce</wicri:regionArea><wicri:noRegion>Lecce</wicri:noRegion></affiliation></author></analytic><series><title level="j">Nutrition research reviews</title><idno type="eISSN">1475-2700</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Mitochondria play an important role in a number of fundamental cellular processes, including energy production, biosynthetic pathways and cellular oxidoreductive homeostasis (redox status), and their dysfunction can lead to numerous pathophysiological consequences. As the biochemical mechanisms orchestrating mitochondrial metabolism and redox homeostasis are functionally linked, mitochondria have been identified as a potential therapeutic target. Consequently, considerable effort has been made to evaluate the efficacy of natural compounds that modulate mitochondrial function. Molecules produced by plants (for example, polyphenols and isothiocyanates) have been shown to modulate mitochondrial metabolism/biogenesis and redox status; however, despite the existence of a functional link, few studies have considered the combined efficacy of these mitochondrial functions. The present review provides a complete overview of the molecular pathways involved in modulating mitochondrial metabolism/biogenesis and redox status. Crosstalk between these critical mechanisms is also discussed, whilst major data from the literature regarding their antioxidant abilities are described and critically analysed. We also provide a summary of recent evidence regarding the ability of several plant-derived compounds to target these mitochondrial functions. An in-depth understanding of the functional link between mitochondrial metabolism/biogenesis and redox status could facilitate the analysis of the biological effects of natural compounds as well as the development of new therapeutic approaches.</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">31615587</PMID><DateRevised><Year>2020</Year><Month>10</Month><Day>08</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1475-2700</ISSN><JournalIssue CitedMedium="Internet"><Volume>33</Volume><Issue>1</Issue><PubDate><Year>2020</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Nutrition research reviews</Title><ISOAbbreviation>Nutr Res Rev</ISOAbbreviation></Journal><ArticleTitle>Crosstalk between mitochondrial metabolism and oxidoreductive homeostasis: a new perspective for understanding the effects of bioactive dietary compounds.</ArticleTitle><Pagination><MedlinePgn>90-101</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1017/S0954422419000210</ELocationID><Abstract><AbstractText>Mitochondria play an important role in a number of fundamental cellular processes, including energy production, biosynthetic pathways and cellular oxidoreductive homeostasis (redox status), and their dysfunction can lead to numerous pathophysiological consequences. As the biochemical mechanisms orchestrating mitochondrial metabolism and redox homeostasis are functionally linked, mitochondria have been identified as a potential therapeutic target. Consequently, considerable effort has been made to evaluate the efficacy of natural compounds that modulate mitochondrial function. Molecules produced by plants (for example, polyphenols and isothiocyanates) have been shown to modulate mitochondrial metabolism/biogenesis and redox status; however, despite the existence of a functional link, few studies have considered the combined efficacy of these mitochondrial functions. The present review provides a complete overview of the molecular pathways involved in modulating mitochondrial metabolism/biogenesis and redox status. Crosstalk between these critical mechanisms is also discussed, whilst major data from the literature regarding their antioxidant abilities are described and critically analysed. We also provide a summary of recent evidence regarding the ability of several plant-derived compounds to target these mitochondrial functions. An in-depth understanding of the functional link between mitochondrial metabolism/biogenesis and redox status could facilitate the analysis of the biological effects of natural compounds as well as the development of new therapeutic approaches.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Di Giacomo</LastName><ForeName>Mariangela</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zara</LastName><ForeName>Vincenzo</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bergamo</LastName><ForeName>Paolo</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Institute of Food Sciences, National Research Council (CNR-ISA), Avellino, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ferramosca</LastName><ForeName>Alessandra</ForeName><Initials>A</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-8251-9652</Identifier><AffiliationInfo><Affiliation>Department of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, Italy.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>10</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Nutr Res Rev</MedlineTA><NlmUniqueID>9113797</NlmUniqueID><ISSNLinking>0954-4224</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Antioxidant mechanisms</Keyword><Keyword MajorTopicYN="N">Bioactive molecules</Keyword><Keyword MajorTopicYN="N">Mitochondrial dysfunction</Keyword><Keyword MajorTopicYN="N">Oxidative stress</Keyword><Keyword MajorTopicYN="N">Reactive oxygen species</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>10</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>10</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>10</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31615587</ArticleId><ArticleId IdType="pii">S0954422419000210</ArticleId><ArticleId IdType="doi">10.1017/S0954422419000210</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Di Giacomo, Mariangela" sort="Di Giacomo, Mariangela" uniqKey="Di Giacomo M" first="Mariangela" last="Di Giacomo">Mariangela Di Giacomo</name></noRegion><name sortKey="Bergamo, Paolo" sort="Bergamo, Paolo" uniqKey="Bergamo P" first="Paolo" last="Bergamo">Paolo Bergamo</name><name sortKey="Ferramosca, Alessandra" sort="Ferramosca, Alessandra" uniqKey="Ferramosca A" first="Alessandra" last="Ferramosca">Alessandra Ferramosca</name><name sortKey="Zara, Vincenzo" sort="Zara, Vincenzo" uniqKey="Zara V" first="Vincenzo" last="Zara">Vincenzo Zara</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Bois/explor/MitoPlantRedoxV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000045 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000045 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Bois
|area= MitoPlantRedoxV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:31615587
|texte= Crosstalk between mitochondrial metabolism and oxidoreductive homeostasis: a new perspective for understanding the effects of bioactive dietary compounds.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:31615587" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a MitoPlantRedoxV1
| This area was generated with Dilib version V0.6.38. |  |